HK Recruiting

Sr Development Scientist, Multiplex Immunoassay Development

HK Recruiting - South San Francisco, CA

You will help develop automated, multiplex immunoassays to analyze patient samples and contribute to our mission of early detection and intervention in human cancer. As a Senior Development Scientist focused on proteomics, you will provide expertise in immunoassays, and associated method development, and analysis. You will contribute to developing, optimizing, and validating clinical-grade assays to accurately and reproducibly measure proteins from blood. You will work closely with engineers to automate the assays and with clinical staff to transfer technologies into a regulated, high-throughput environment. You will use your analytical and programming abilities to identify ways to rapidly iterate and improve on existing methods, and you will work closely with computational biologists to evaluate technologies that can enhance our end-to-end test performance. 


  • Apply expert knowledge of protein biochemistry to develop quantitative, multiplex assays.

  • Develop assays by converting manual prototypes into optimized, high-throughput validated assays.

  • Analyze existing and development method data to identify workflow and protocol improvements.

  • Lead from the bench by training and mentoring scientists while also performing your own experiments in order to facilitate rapid progress toward project goals.

  • Collaborate with computational biologists and software engineers to build analysis pipelines and to integrate new molecular technologies into analytical workflows.

  • Collaborate with clinical laboratory members to transition development protocols into production, including automation, validation experiments, and SOP development.


  • PhD (or equivalent industry experience) in biochemistry, immunology, genetics, chemistry, or a related field with 3+ years post-PhD experience in protein-based assay development

  • Broad, expert-level knowledge of protein assays, including general protein biochemistry as well as specific optimizations for antibody-based methods (e.g. ELISAs, Western blots) and common analytical platforms (e.g. Luminex, MSD).

  • Proven track record of establishing new methods that go beyond kitted assays.

  • Ability to design for automated platforms in plate-based, low-volume formats and/or microfluidics and experience working with automated liquid handlers.

  • Hands-on proficiency in managing technology transfer requirements, including guard-banding, stability studies, and in-process quality control.

  • Experience working in a regulated laboratory environment (CLIA, GLP/GCLP, IVD development).

  • Clear communications skills and ability to work with team members in the same and adjacent disciplines.

  • Understanding of immunology, cancer biology, and/or the biology of human plasma.

  • Experience mentoring and training research associates and junior scientists

We have adopted a COVID-19 vaccination policy to safeguard the health and well-being of our employees. As a condition of employment, our employees working on-site are required to be fully vaccinated for COVID-19, unless a reasonable accommodation is approved or as otherwise required by law. 

Posted On: Tuesday, December 28, 2021

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