You will help develop the assay technologies used to analyze patient samples and contribute to our mission of early detection and intervention in human disease. As a (Senior) Development Scientist, you will provide expertise in next-generation-sequencing (NGS)-based analyses of DNA and RNA. Starting with a prototype assay, you will contribute to developing, optimizing, and validating clinical-grade assays to measure complex, blood-based analytes (e.g., whole-genome sequencing of cfDNA). You will work closely with multiple teams including research team, process engineers, computational science team, and clinical operations to develop and optimize the assays in a regulated, high-throughput environment as well as identify ways to rapidly iterate and improve on existing methods to evaluate technologies that can enhance our end-to-end test performance. RESPONSIBILITIES Apply expert knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA and RNA, including genome-wide and targeted approaches Develop assays by converting manual prototypes into optimized, high-throughput validated assays Identify workflow and protocol improvement by analyzing and developing method data Lead from the bench by training and mentoring scientists while also performing your own experiments in order to facilitate rapid progress toward project goals. Collaborate with computational biologists and software engineers to build analysis pipelines and to integrate new molecular technologies into analytical workflows. Collaborate with clinical laboratory members to transition development protocols into production, including automation, validation experiments, and SOP development. Present data in cross functional teams Document product development requirements and author study protocols and reports QUALIFICATIONS PhD (or equivalent industry experience) in molecular biology, biochemistry, genetics, chemistry, or a related field 3+ years post-PhD experience in NGS-based assay development for Senior-level Scientist Extensive hands-on experience in NGS based assay development including sample preparation, library preparation, target capture, and sequencing Proven track record of establishing new methods for NGS-based measurements of biology (*-seq) that go beyond kitted assays Familiarity with programing in a scientific programming language (e.g., Python or R) and perform bioinformatics analyses to enable experimental iteration independent of external support Ability to design for automated platforms in plate-based, low-volume formats and/or microfluidics and experience working with automated liquid handlers. Biological understanding of human cell-free nucleic acids, single-cell analysis methods, immunology, and/or cancer biology. Hands-on proficiency in managing technology transfer requirements, including guard-banding, stability studies, and in-process quality control. Experience working in a regulated laboratory environment (CLIA, GLP/GCLP, IVD development). Clear communications skills and ability to work with team members in the same and adjacent disciplines Experience mentoring and training junior scientists Sense of humor is a must. We have adopted a COVID-19 vaccination policy to safeguard the health and well-being of our employees. As a condition of employment, our employees working on-site are required to be fully vaccinated for COVID-19, unless a reasonable accommodation is approved or as otherwise required by law.
Posted On: Tuesday, December 28, 2021