HK Recruiting

(Senior) Development Scientist, NGS

HK Recruiting - South San Francisco, CA

You will help develop the assay technologies used to analyze patient samples and contribute to our mission of early detection and intervention in human disease. As a (Senior) Development Scientist, you will provide expertise in next-generation-sequencing (NGS)-based analyses of DNA and RNA. Starting with a prototype assay, you will contribute to developing, optimizing, and validating clinical-grade assays to measure complex, blood-based analytes (e.g., whole-genome sequencing of cfDNA). You will work closely with multiple teams including research team, process engineers, computational science team, and clinical operations to develop and optimize the assays in a regulated, high-throughput environment as well as identify ways to rapidly iterate and improve on existing methods to evaluate technologies that can enhance our end-to-end test performance.


  • Apply expert knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA and RNA, including genome-wide and targeted approaches

  • Develop assays by converting manual prototypes into optimized, high-throughput validated assays

  • Identify workflow and protocol improvement by analyzing and developing method data

  • Lead from the bench by training and mentoring scientists while also performing your own experiments in order to facilitate rapid progress toward project goals.

  • Collaborate with computational biologists and software engineers to build analysis pipelines and to integrate new molecular technologies into analytical workflows.

  • Collaborate with clinical laboratory members to transition development protocols into production, including automation, validation experiments, and SOP development.

  • Present data in cross functional teams

  • Document product development requirements and author study protocols and reports 


  • PhD (or equivalent industry experience) in molecular biology, biochemistry, genetics, chemistry, or a related field

  • 3+ years post-PhD experience in NGS-based assay development for Senior-level Scientist

  • Extensive hands-on experience in NGS based assay development including sample preparation, library preparation, target capture, and sequencing

  • Proven track record of establishing new methods for NGS-based measurements of biology (*-seq) that go beyond kitted assays

  • Familiarity with programing in a scientific programming language (e.g., Python or R) and perform bioinformatics analyses to enable experimental iteration independent of external support

  • Ability to design for automated platforms in plate-based, low-volume formats and/or microfluidics and experience working with automated liquid handlers.

  • Biological understanding of human cell-free nucleic acids, single-cell analysis methods, immunology, and/or cancer biology.

  • Hands-on proficiency in managing technology transfer requirements, including guard-banding, stability studies, and in-process quality control.

  • Experience working in a regulated laboratory environment (CLIA, GLP/GCLP, IVD development).

  • Clear communications skills and ability to work with team members in the same and adjacent disciplines

  • Experience mentoring and training junior scientists

  • Sense of humor is a must.

We have adopted a COVID-19 vaccination policy to safeguard the health and well-being of our employees. As a condition of employment, our employees working on-site are required to be fully vaccinated for COVID-19, unless a reasonable accommodation is approved or as otherwise required by law. 

Posted On: Tuesday, December 28, 2021

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