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Principal Scientist, DMPK $180K

Snap Staffing - San Diego, CA

Principal Scientist, DMPK (San Diego, CA)


Our client is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We are uniquely structured with opportunities for all scientists to contribute to both established programs as well as ongoing early target selection, screens and validation. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.


Experience and education requirements:

  • Ph.D. in pharmacokinetics or a closely related discipline
  • 8+ years of experience in DMPK-related positions within a pharmaceutical or biotechnology company
  • An in-depth understanding of all aspects of DMPK with experience in drug discovery settings
  • In-depth understanding of in vitro and in vivo ADME assays, methods, and models.
  • Assist in the design, conduct, and data interpretation of in vitro and in vivo pharmacokinetic/toxicokinetic, ADME and in vitro drug-drug interaction studies.
  • The ability to work in team-based drug discovery/development environments is required
  • Must be able to design and perform both routine and mechanistic animal PK studies
  • Hands on experience with different biological samples and sample preparation techniques to generate qualitative and quantitative data along with operation of HPLC and LC/MS/MS instrumentation is highly desired
  • Experience with pre-clinical pharmacokinetic protocol design
  • Experience working with CROs


For immediate consideration, please send your resume to!


Posted On: Thursday, April 7, 2022

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